疏水性离子液体萃取光甘草定

Extraction of glabridin using hydrophobic ionic liquids

选择了疏水性的离子液体1-丁基-3-甲基咪唑六氟磷酸盐([C4mim][PF6])和亲水性的离子液体1-丁基-3-甲基咪唑四氟硼酸盐([C4mim][BF4])作萃取剂,对光甘草定提取液进行了萃取,并对离子液体的再生进行了研究。结果表明,亲水性的离子液体和光甘草定提取液无法分层,而疏水性的离子液体分层清晰,并得疏水性离子液体[C4mim][PF6]萃取光甘草定最佳萃取工艺条件为:相体积比为1∶2.5(V/V),pH值为7,萃取温度为45℃,萃取时间为30 min,此时光甘草定的萃取率达85.49%。离子液体再生选用2 mol.L-1氢氧化钠和无水乙醇混合液做反萃剂,可得光甘草定的回收率大于90%,离子液体循环使用5次,萃取率未见明显下降。

The hydrophobic ionic liquid of 1-butyl-3-methylimidasolium hexafluorophosphate（ [ C, mim] [ PF6 ] ）and the hydrophilic ionic liquid of 1-butyl-3-methylimidazalium tetrafluoroberate（ [ C4 mim ] [ BF4 ] ）were selected to extract glabridin. The regeneration of ionic liquids was investigated. The resuhs indicates that the hydrophilic ionic liquid could not be layered with glabridin extract, and the hydrophobic ionic liquid layer clearly, and the extraction efficiency of glabridin using the hydrophobic [ C4 mira ] [ PF6 ] could reach to 85.49% under phase volume ratio of 1：2. 5 （ V/V）, pH value of solution was 7, the temperature of solution was 45℃and extraction time 30 min. The 2 mol·L-1 sodium hydroxide and ethanol was selected as back extractant to regenerate ionic liquids, the recovey of glabridin could be greater than 90%. After five cycles of extraction, the extraction efficiency of glabridin did not sig- nificantly decrease.