摘要
以β-碳苷酮为母体化合物,经选择性保护糖环4,6-位羟基及在发烟硝酸-乙酸酐体系中的硝化反应,合成了一系列结构新颖的β-碳苷硝酸酯类化合物,为新药研发及构效关系的研究提供全新的候选化合物。
A series of novel β-C-glycosidic nitrate esters were synthesized from β-C-glycosidic ketones, through selective protection of the 4,6-position hydroxyl of pyranose ring and nitration reaction using fuming nitric acid in acetic anhydride,which are new can- didate compounds for new drug development and structure-activity relationship study.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2013年第2期229-235,共7页
Chemical Research and Application
关键词
β-碳苷
硝酸酯
硝化
心血管疾病
β-C-Glycoside
nitrate esters
nitration
cardiovascular disease
