初诊2型糖尿病患者血清晚期糖基化终末产物、可溶性糖基化终末产物受体水平分析

Analysis of serum AGEs and sRAGE levels in newly diagnosed patients with type 2diabetes

目的了解初诊2型糖尿病患者血清晚期糖基化终末产物（AGEs）、可溶性糖基化终末产物受体（sRAGE）水平，为预防初诊2型糖尿病并发症的发生、延缓其发展提供依据。方法收集2010年9月至2011年12月江苏省常熟市中医院（新区医院）内分泌科初诊为2型糖尿病的患者56例，另筛选健康人群30例为对照组，检测各类临床及生化指标，采用酶联免疫吸附法检测血清AGEs、sRAGE水平。结果初诊2型糖尿病患者血清AGEs水平（1379．2±431．8）pg／roa与对照组（1154．5±326．4）pg／ml比较差异有统计学意义（P〈0．05）；血清sRAGE水平（14．6±9．3）ng／wa与对照组（19．5±8．9）ng／wa比较差异有统计学意义（P〈O．05）。初诊2型糖尿病患者血清AGEs水平与糖化血红蛋白（HbAle）水平正相关，血清sRAGE水平与低密度脂蛋白胆固醇（LDL-c）负相关。结论初诊2型糖尿病患者血清AGEs水平高于正常人群、血清sRAGE水平低于正常人群。

Objective To understand the serum levels of advanced glycation end products （AGEs）, soluble receptor for advanced glycation end products （sRAGE） in newly diagnosed patients with type 2 diabetes. Methods 60 patients of newly diagnosed type 2 diabetes were chosen from 2010 September to 2011 December in Department of Endocrinology Changshou Chinese medicine hospital in Jiangsu Province, and 30 healthy people were screened as control group. Various clinical and biochemical parameters were detected, using enzyme-linked immunosorbent assay for the detection of serum AGEs and sRAGE levels. Results The levels of serum AGEs in newly diagnosed type 2 diabetic patients and control group were （1379.2 ±431.8） and （1154.5 ± 326.4） pg/ml, and there were significant differences between two groups （P〈0.05）. The levels of serum sRAGE in newly diagnosed type 2 diabetic patients and control group were （14.6 ± 9.3）and （19.5 ± 8.9）ng/ml, and there were also significant differences between two groups （P〈0.05）. The level of serum AGEs in newly diagnosed type 2 diabetic patients was positive correlation with glycosylated hemoglobin （HbAlc）, and the level of serum sRAGE was associated with low density lipoprotein cholesterol （LDL-C） negative correlation. Conclusion The level of serum AGEs increase in newly diagnosed type 2 diabetic patients, and the level of serum sRAGE decrease in newly diagnosed type 2 diabetic patients.