血管内皮生长因子与磷脂酰肌醇3-激酶／蛋白激酶B信号传导通路在早产儿视网膜病变中的作用

Effect of vascular endothelial growth factor and phosphoinositide 3-kinase in retinopathy of prematurity

血管内皮生长因子（vascular endothelial growth factor，VEGF）可在体内诱导血管新生。磷脂酰肌醇3．激酶／蛋白激酶B（phosphoinositide 3-kinase／protein kinase B，PDK—AKt）信号通路广泛存在细胞中，在细胞生长、增殖、分化调节、血管新生等过程中发挥着重要作用。PDK—AKt信号通路可通过缺氧诱导因子-1、胰岛素样生长因子-Ⅰ、一氧化氮合酶、环氧化酶等多种途径激活VEGF的表达。研究显示VEGF、PDK．AKt信号通路在早产儿视网膜病变的发病机制中起重要作用。

Vascular endothelial growth factor can induce angiogenesis in vivo. Phosphoinositide 3-kinase signaling pathway widespreads in cells, which plays important roles in cell growth, proliferation, differentiation, and angiogenesis. The phosphoinositide 3-kinase signaling pathway can activate vascular endothelial growth fac-tor,such as hypoxia-inducible factor-1 ,insulin-like growth factor-Ⅰ, nitric oxide synthaseand cyclooxygenase-2. The present studies have shown that the vascular endothelial growth factor and phosphoinositide 3-kinase signa-ling pathway play an important role in the retinopathy of prematurity.