腔隙性脑梗死患者血清缺血修饰清蛋白和高敏C-反应蛋白的研究

Exploration of IMA and hs-CRP in acute period of lacunar infarction

目的探讨腔隙性脑梗死与血清缺血修饰清蛋白(IMA)和高敏C-反应蛋白(hs-CRP)水平的关系。方法测定30例有临床症状的腔隙性脑梗死患者(腔隙性脑梗死组)入院后第1、3、5和7天血清IMA和hs-CRP的水平,与30例健康对照者(对照组)血清IMA和hs-CRP水平比较。结果腔隙性脑梗死组入院后第1、3、5和7天血清IMA水平分别为(92±20.1)、(103±17.3)、(85±19.5)和(68±15.0)U/mL,高于对照组[(47±5.2)U/mL,P<0.01];腔隙性脑梗死组入院后第1、3、5和7天血清hs-CRP水平分别为(13.1±3.6)、(11.3±3.0)、(8.1±2.2)和(6.2±2.0)mg/L,高于对照组[(1.0±0.3)mg/L,P<0.01]。血清IMA水平峰值出现在入院后第3天,而血清hs-CRP水平峰值出现在入院后第1天。结论缺血和炎性反应参与了腔隙性脑梗死的病理生理过程中。

Objective To observe the changes of ischemia-modified albumin（IMA） and hypersensitive C-reactive protein（hs- CRP） in acute period of lacunar infarction. Methods 30 patients with lacunar infarction were enrolled as LAC group,and were de- tected for serum levels of IMA and hs-CRP on the first, third, fifth and seventh day after admission. 30 healthy subjects were en- rolled as control group. Results Serum levels of IMA and hs-CRP in LAC group were higher than those in control group on the first,third,fifth and seventh day（P〈0.01）. Serum IMA level of LAC group increased to the top on the third day. The serum hs- CRP level of LAC group increased to the top on the first day. Conclusion Ischemic injury and inflammation could play a role in the attack of lacunar infarction.