未成熟网织红细胞分数对评估38例恶性肿瘤患者放疗后造血功能恢复情况的分析

Evaluation of haematopoietic function recovery in 38 malignant tumor cases after radiotherapy by immature reticulocyte fraction

目的探讨采用未成熟网织红细胞分数(IRF)监测恶性肿瘤患者放疗后造血功能恢复的临床价值。方法采用Sysmex XE-2100全自动血细胞分析仪检测38例恶性肿瘤患者的中性粒细胞绝对计数(ANC)、网织红细胞百分比(RET%)及IRF,并对结果进行对比分析。结果 38例恶性肿瘤患者放疗后ANC、RET%及IRF与放疗前相比均明显降低(P<0.05)。随着恢复时间的延长,各指标均开始回升,第20天时IRF与化疗前相比差异无统计学意义(P>0.05),而ANC及RET%仍显著低于放疗前水平(P<0.05)。结论 IRF是恶性肿瘤患者放疗后造血功能恢复较敏感的指标,可用于造血功能恢复的监测、病情观察及指导临床治疗。

Objective To investigate the clinical value of immature reticulocyte fraction（IRF） in evaluating the recovery of blood-producing function after radiotherapy. Methods Count number of absoluteneutrophilic granulocyte count（ANC）, percentage of retieulocyte（RET%） and IRF in 38 patients with malignant tumor before and after radiotherapy was detected by Sysmex XE- 2100 automated hematology analyzer and the results were compared. Results After radiotherapy, IRF, ANC and RET% were sig- nificantly decreased（P〈0.05）. IRF, ANC and RET% began to increase with duration of recovery. On the 20th day, there were no significant changes in the level of IRF between post-radiotherapy and pre-radiotherapy（P〉0.05）. While ANC and RET% were still significantly lower than those of pre-radiotherapy（P〈0.05）. Conclusion IRF could be an early indicator of haematopoietic function recovery after radiotherapy, and it could be applied to monitor hemopoietic recovery after radiotherapy, observe pathoge- netic condition and guide the treatment.