化瘀通络方治疗寻常型银屑病的临床观察

Clinical Observation of Psoriasis Vulgaris Treated with Huayu Tongluo Formula

观察化瘀通络方治疗寻常型银屑病血瘀证的临床疗效及其对血液流变学指标的影响。方法将120例寻常型银屑病患者随机分为两组。治疗组60例采用口服中药化瘀通络方进行治疗,每日2次;对照组60例采用消银颗粒口服,每次3.5 g,每日3次。两组患者同时外用10%硫磺软膏,每日3次。两组均以4周为1个疗程。两个疗程后依据治疗前后PASI评分判定临床疗效,并检测治疗组治疗前后血液流变学指标,探讨其治疗银屑病的作用机制。结果两组总有效率分别为83.33%、56.67%,两组总有效率比较,差异有统计学意义(P<0.01);治疗组治疗后血液流变学指标明显改善,与治疗前比较,差异有统计学意义(P<0.05)。结论化瘀通络方治疗寻常型银屑病血瘀证有较好的临床疗效,且能明显改善血液流变性。

Objective To observe the clinical efficacy on psoriasis vulgaris of blood stagnation pattern/syndrome treated with huayu tongluo formula and the impacts on the indexes of haemorheology.Methods One hundred and twenty cases of psoriasis vulgaris were randomized into two groups.In a treatment group,60 cases were treated with huayu tongluo formula for oral administration,twice a day.In a control group,60 cases were treated with xiaoyin granules,3.5 g each time,three times a day.10% sulfur ointment was used for the patients in two groups for external application,three times a day.The treatment of 4 weeks made 1 session in two groups.PASI score was evaluated before and after treatment to determine the clinical efficacy after 2 sessions of treatment.The indexes of haemorheology were determined before and after treatment in the treatment group to explore the mechanism on the treatment of psoriasis.Results The total effective rate were 83.33% and 56.67% in two groups respectively,presenting the statistical significant difference in comparison（P〈0.01）.The indexes of haemorheology were improved apparently after treatment as compared with those before treatment in the treatment group,presenting the statistical significant difference（P〈0.05）.Conclusion Huayu tongluo formula achieves a satisfactory clinical efficacy on psoriasis vulgaris of blood stagnation pattern/syndrome and apparently improves haemorheological property.