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脑胶质瘤细胞、组织中PGAM1 mRNA、蛋白的表达变化及意义 被引量：2

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摘要 目的观察脑胶质瘤细胞、组织中磷酸甘油酸变位酶1(PGAM1)mRNA及其蛋白的表达变化。方法用半定量RT-PCR检测大鼠C6胶质瘤组织和星形胶质细胞中的PGAM1 mRNA。用免疫组化法检测43例人脑胶质瘤组织标本(胶质瘤组)和15例瘤周脑组织(对照组)中的PGAM1蛋白。结果星形胶质细胞中PGAM1 mRNA表达量为1.26±0.05,C6胶质瘤细胞中为0.75±0.07,二者相比P<0.05。对照组、胶质瘤组PGAM1蛋白阳性表达分别为3、29例,两组相比,P<0.05。结论脑胶质瘤组织中PGAM1 mRNA、蛋白表达增高,可能与脑胶质瘤的发病有关。
作者 刘志国 李连陵 王通
机构地区 章丘市人民医院 山东大学齐鲁医院
出处 《山东医药》 CAS 2013年第2期56-58,共3页 Shandong Medical Journal
关键词 脑肿瘤 胶质瘤 磷酸甘油酸变位酶1
分类号 R737.9 [医药卫生—肿瘤]
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参考文献12

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共引文献8

同被引文献16

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山东医药
2013年 第2期

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