41例自体外周血造血干细胞移植治疗POEMS综合征的护理

Nursing of 41 patients with POEMS syndrome treated by autologous peripheral blood stem cell transplantation

回顾分析41例POEMS综合征患者进行自体外周造血干细胞移植治疗之后的护理要点。患者移植前状态不良,存在多发性周围神经病、肌无力、肝脾肿大、胸水和腹水、男性患者雌激素水平升高、性功能减退等问题,护理要点为周围神经病、肌无力的护理、预防感染、男性性格女性化的应对、植入综合征及不良反应的观察及护理,取得了较好的效果,住院期间死亡2例,随访中死亡3例,其余存活患者疾病均无再次进展。

This paper summarizes the nursing care of 41 patients with POEMS（polyneuropathy,organomegaly,endoc-rinopathy, M-protein and skin changes） syndrome treated by autologous peripheral blood stem cell transplantation（AUTO-PBSCT）. All the patients were in poor situation before PBSCT manifested with problems such as polyneuropathy,myasthenia,hepatosplenomegaly, pleural effusion and ascites,high level and estrogen in male and lower sexual activity. The key points in nursing were symptomatic care of peripheral neuropathies and myasthenia,prevention of infections,coping with feminization in male, observation of engraftment syndrome and adverse reactions. Totally 2 cases died during hospitalization and 3 cases died during follow-up. The rest of the patient＇s condition do not make progress.