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肺高血压与铁代谢异常 被引量:2

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摘要 近年来诸多研究者就肺高血压发病机制,病理进程及药物治疗靶点等方面进行了深入研究。2011年欧洲三个独立的实验室先后报道在特发性肺动脉高压(idiopathic pulmonary anerial hypertension,IPAH)人群中出现铁缺乏、铁代谢紊乱,其发病机制尚不明确;另外有研究发现,
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2013年第1期76-78,共3页 Chinese Journal of Cardiology
基金 国家“重大新药创制”科技重大专项(2012zx09303014-001) 重大基础研究前期研究专项(2011CB512001) 湖南省国际合作科技计划重点项目(2010WK2006) 国家自然科学基金(81200035)
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  • 1Vincent G DeMarco,Adam T Whaley-Connell,James R Sowers,Javad Habibi,Kevin C Dellsperger.Contribution of oxidative stress to pulmonary arterial hypertension[J].World Journal of Cardiology,2010,2(10):316-324. 被引量:21
  • 2McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a re- port of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Associa- tion developed in collaboration with the American College of Chest Physicians ; American Thoracic Society, Inc ; and the Pul- monary Hypertension Association [ J ]. J Am Coll Cardiol, 2009, 53(17) : 1573-1619.
  • 3Simes PA, Tendera M, Vardas P, et al. Guidelines for the diag- nosis and treatment of pulmonary hypertension[J]. Eur Heart J, 2009, 30: 2493-2537.
  • 4Soon E, Treacy CM, Toshner MR, et al. Unexplained iron defi- ciency in idiopathic and heritable pulmonary arterial hypertension [J]. Thorax, 2011,66(4) : 326-332.
  • 5Ruiter G, Lankhorst S, Boonstra A, et al. Iron deficiency is com- mon in idiopathic pulmonary arterial hypertension[ J]. Eur Respir J, 2011, 37(6) : 1386-1391.
  • 6Rhodes CJ, Howard KS, Busbridge M, et al. Ilron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension : clin- ical prevalence, outcomes, and mechanistic insights [ J ]. J Am Coll Cardiol, 2011, 58(3): 300-309.
  • 7van Empel VP, Lee J, Williams TJ, et al. Iron deficiency in pa- tients with idiopathic pulmonary arterial hypertension [ J ]. Heart Lung Circ, 2014, 23(3): 287-292.
  • 8Smith TG, Balanos GM, Croft QP, et al. The increase in pulmo- nary arterial pressure caused by hypoxia depends on iron status [ J]. J Physiol, 2008, 586(Pt 24): 5999-6005.
  • 9Smith TG, Talbot NP, Privat C, et al. Effects of iron supplemen- tation and depletion on hypoxic pulmonary hypertension: two ran- domized controlled trials [ J ]. JAMA, 2009, 302 ( 13 ) : 1444- 1450.
  • 10Finch CA, Miller LR, lnamdar AR, et al. Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction [J]. J Clin Invest, 1976, 58(2) : 447-453.

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