药物源性角膜病变诊断和治疗中的几个问题

Noticeable problem in diagnosis and treatment of drug-induced keratopathy

由于滴眼剂应用后存在一定的不良反应和临床用药不规范，药物源性角膜病变的报道呈逐年增多的趋势，其临床表现多样，容易出现误诊和漏诊。另外，不同滴眼剂在所致角膜病变中的发病机制各异，患者自身的病情也不尽相同，临床治疗十分棘手。因此，眼科医师应重视滴眼剂对眼表的毒性作用和所致的角膜病变，减少药物源性角膜病变的发生。

Ocular surface disorders can be caused by the drug-derived toxicity,adverse effect and abuse ol eye drops, and usually these disorders present with unspecific and untypical clinical findings. So the eye abnormality induced by topical administration of eye drops often is confused with some corneal inflammatory diseases. In addition, pathogenic mechanisms vary widely due to the different types of eye drops. Therefore, difficulty of diagnosis and poor curative effect often is a challenge for us. Ophthalmologist should be aware of the toxicity derived eye drops on ocular surface. Several noticeable problems of diagnosis and treatment of drug-derived keratopathy were elaborated in this paper