女性冠心病患者高密度脂蛋白亚组分的检测及临床意义

Detection and clinical significance of high-density lipoprotein subfractions in women with coronary heart disease

目的研究女性冠心病患者高密度脂蛋白(HDL)亚组分及相对含量的变化并分析其临床意义。方法采用双相电泳-免疫印迹法分析78例女性冠心病患者(观察组)及82例女性非冠心病组(对照组)血清HDL各亚组分的含量。结果观察组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、LDL-C/HDL-C的值明显高于对照组,而HDL-C明显低于对照组,差异均有统计学意义(P<0.01);女性冠心病患者血清中Preβ1-HDL、HDL-3b、HDL-3c水平显著高于对照组,差异有统计学意义(P均<0.05),而HDL-2b水平显著低于对照组(P<0.05)。结论女性冠心病患者血清中,HDL颗粒有变小的趋势,HDL-2b预测冠心病的可能性更高。

Objective To evaluate the clinical significance of high-density lipoprotein subfractions in women with coronary heart disease. Method 78 female patients with coronary artery disease （observation group） and 82 normal subjects （control group） were analyzed for the serum HDL using two-dimensional gel-electrophoresis. Results In the observation group,the levels of TC,TG,LDL-C, and the ratio of LDL-C/HDL-C were significantly higher than the control group.The level of HDL-C in the observation group was significantly lower than the control group （P〈0.01）. The levels of serum Preβ1-HDL, HDL-3b, and HDL-3c were also significantly higher than the control group （P〈0.05）.In contrast,the level of HDL-2b was significantly lower than the control group （P〈0.05）, suggesting that the HDL tended to be smaller in women with coronary heart disease. Conclusions Women with coronary heart disease tended to have smaller HDL particles.HDL-2b can be used to predict the likelihood of coronary heart disease.