腺样体肥大与白细胞介素6及耳鼻咽喉并发症的相关性分析

Correlation analysis of adenoids and IL-6 and ENT complications

目的探讨腺样体肥大与白细胞介素6(interleukin 6,IL-6)及耳鼻咽喉并发症的关系。方法腺样体肥大患者79例,对所有病例行腺样体手术,在术前和术后1个月行鼻内镜检查、声导抗、电测听检测以及ELISA法检测lL-6。结果①腺样体切除后耳鼻咽喉并发症均得到有效改善;②术后阻塞性睡眠呼吸暂停低通气综合征、分泌性中耳炎、慢性鼻及鼻窦炎和听力下降的发生显著少于术前(x^2=15.3、9.5、13.2、5.8,P均<0.05);③腺样体肥大与IL-6、阻塞性睡眠呼吸暂停低通气综合征、分泌性中耳炎、慢性鼻及鼻窦炎、听力下降成正相关(r=0.51、0.42、0.46、0.37、0.34,P均<0.05)。结论腺样体肥大通过炎症反应和机械性堵塞与耳鼻咽喉并发症的发生发展密切相关,切除腺样体可以有效治疗各种并发症。

OBJECTIVE To study the relationship between the adenoid hypertrophy and IL-6, obstructive sleep apnea hypopnea syndrome （OSAHS） , chronic rhinosinusitis （CRS） , otitis media with effusion （OME） . METHODS 79 patients with adenoid hypertrophy were chosen in otolaryngology.Adenoidectomy were done in all patients. The nasopharynx were examinated by nasal endoscopy. The hearing was detected by acoustic impedance and pure tone audiometry. The change of symptoms was questioned before operation and at 1 month postoperatively. The IL-6 of serum and adenoids were measured by ELISA. RESULTS 1. The ENT complications were effectively improved after operation; 2. There were statistical significant difference between OSAHS, OME, CRS and hearing loss before and after operation （χ2=15.3, 9.5, 13.2, 5.8, P〈0.05） ; 3. There were positive correlation between adenoids classification and IL-6, OSAHS, CRS, OME and hearing loss （r=0.51, 0.42, 0.46, 0.37, 0.34, P〈0.05） . CONCLUSION The adenoid hypertrophy is closely related to the development of ENT complications through the inflammatory reaction and mechanical occlusion. Adenoidectomy can be effective to treat all related ENT complications.