诱导多能干细胞在眼科疾病的研究进展

Progress of induced pluripotent stem cells in ophthalmic diseases

可诱导多能干细胞(induced pluripotent stem cells,iPSC)是由体细胞或成体细胞重编程转化而来,这项技术引起了学术界空前的关注,越来越多的相关研究随之开展。它是通过人工方法将适当的外源性转录因子导入体细胞或成体干细胞,使之转化为具有无限增殖潜能和定向分化能力、类似于胚胎干细胞的一类干细胞。在不断探索发展多能干细胞培养转化技术的过程中,已经取得不少突破性的进展,这为将来细胞移植成为临床治疗方法奠定了基础。同时各种研究成功诱导出类似人体细胞的干细胞,并在动物实验中得到乐观的结果。我们主要探讨iPSC在眼科疾病方面的研究进展。

Induced pluripotent stem cells （ iPSCs ） are reprogrammed through transduction of exogenous transcription factors, into somatic cells, reprogramming the somatic cells to embryonic stem cells-like cells with potencies of unlimited proliferation and pluripotent differentiation. This technology is a milestone in the field of regenerative medicine, and many related studies have been made these years. In the development of iPSCs technology, we have achieved a lot of progress; these will lay a foundation of cell therapy. Meanwhile, the successfully reprogrammed human somatic stem cells and good results in the study of animal models have been achieved. This article aims to emphasize the development of iPSCs in Ophthalmology.