中心性浆液性脉络膜视网膜病变激光治疗后视功能的变化

Changes in visual function before and after laser photocoagulation of central serous chorioretinapathy

目的:观察激光治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)的疗效及对视功能的影响。方法:对临床确诊的60例60眼CSC患者,随机分成激光治疗组与药物治疗组,每组各30例30眼。观察两组患者治疗前后视力与mfERG的变化,随访6mo。结果:激光治疗组无1例复发,1mo后视力治疗有效率92.35%。药物治疗组1mo后视力治疗有效率49.58%,复发率13.33%。激光治疗组mfERG显示2～4环的反应密度均高于药物治疗组,N1波潜伏期在4环、P1波潜伏期在3～5环与药物治疗组相比有统计学差异(P<0.05)。结论:CSC早期应用激光治疗可以明显改善视功能,阻止病情恶化,提高治愈率,降低复发率。

AIM ： To observe the clinical aser in treatment of centra effect and visual function of serous chorioretinopathy （CSC）. METHODS. Totally 60 cases clinically diagnosed with CSC were randomly divided into laser treatment group and drug treatment group, 30 cases in each group. Visual acuity and changes of mfERG in two groups were observed, and patients were followed up for 6 months. RESULTS. The treatment of vision effective rate in laser treatment group was 92.35% and after one month with no patient recrudesced. The treatment of vision effective rate in drug treatment group was 49.58% and the recurrence rate was 13.33%. mfERG showed the response densities of ring 2, ring 3, ring 4 and ring 5 areas in laser treatment group were significantly increased while the latencies of ring 4 of N1 wave and the latencies of ring 3, ring 4 and ring 5 of P1 wave were significantly different with drug treatment group（P〈0.05）. CONCLUSION： Early treatment of CSC with laser can significantly improve visual function and recovery rate, prevent disease progression, and decrease the recurrence rate. especially at early stage of the disease.