自体角膜缘干细胞移植联合rh-EGF治疗翼状胬肉疗效观察

Clinical observation on treatment of pterygium with corneal limbal stem cells autograft transplantation combined with rh-EGF

目的:比较下方自体角膜缘干细胞移植联合重组人表皮生长因子滴眼液与单纯翼状胬肉切除术治疗翼状胬肉的疗效。方法:翼状胬肉患者46例50眼,随机分为两组,A组为下方自体角膜缘干细胞移植联合重组人表皮生长因子滴眼液治疗组24例25眼,B组为单纯翼状胬肉切除术治疗组22例25眼,术后随访2a,观察并比较两组角膜上皮修复时间及胬肉复发率。结果:A组角膜上皮修复时间平均为2.96±0.73d,B组角膜上皮修复时间平均为5.64±1.00d,两组比较差异有显著性意义(t=2.17,P<0.05),A组胬肉复发率为4%,B组胬肉复发率为24%,两组比较差异有显著性意义(χ2=4.15,P<0.05)。结论:下方自体角膜缘干细胞移植联合重组人表皮生长因子滴眼液治疗翼状胬肉疗效较好,且复发率低。

AIM： To compare the therapeutic effects of pterygium treated by inferior corneal limbal stem cells autograft transplantation combined with rh- EGF eye drops and simple excision of pterygium. METHODS： Totally 46 cases（50 eyes） with pterygium were divided into two groups according to the operative method. Group A had 24 cases （25 eyes） which were treated by inferior corneal limbal stem cells autograft transplantation combined with rh-EGF eye drops. Group B had 22 cases（25 eyes） which were treated by simple excision of pterygium. After following up for two years, recovered time of corneal epithelia and recurrent rate of the two groups were observed and compared. RESULTS： The average recovery time of corneal epithelia of group A was 2.96± 0.73 days. The average recovered time of corneal epithelia of group B was 5.64± 1. 00 days. The difference of the two groups was significant （t=2.17, P〈0.05）. The recurrent rate of group A was 4%. The recurrent rate of group B was 24%. The difference of the two groups was significant （X2=4.15, P〈 0.05）. CONCLUSION： Inferior corneallimbal stem cells autograft transplantation combined with rh- EGF eye drops which can reduce the recurrent rate is an effective method to treat Dtervoium.