环丙沙星壳聚糖微球的制备

Preparation of Ciprofloxacin Chitosan Microspheres

以戊二醛作为交联剂,采用反相乳化法制备支气管镜介入治疗用环丙沙星壳聚糖微球。采用单因素法和正交试验优化了处方中影响制品外观、平均粒径、载药量和包封率的因素。按优化处方制备的微球外观圆整,平均粒径(142.31±7.85)m,载药量(14.20±0.61)%,包封率(56.43±1.31)%。体外释放行为符合Higuchi方程,2 h和48 h时累积释放率分别为44.3%和92.1%,提示制品具有缓释效果,有利于减少给药频次。

The ciprofloxacin chitosan microspheres for interventional bronchoscopy were prepared by phase inversion emulsification with glutaraldehyde as the crosslinking agent. The influence factors on appearance, average particle size, drug loading and encapsulation efficiency were optimized by single factor test and orthogonal design. The optimal product was spherical with the average particle size of （142.31±7.85） μm. The drug loading and encapsulation efficiency were （14.20±0.61） % and （56.43±1.31） %, respectively. The in vitro release of the product fitted to Higuchi equation. The cumulative amount at 2 h and 48 h were 44.3 % and 92.1%, respectively. It indicated that the product had a sustained-release property, so that it might reduce the administration frequency.