人乳头状瘤病毒L1蛋白在宫颈病变中的表达及其意义

The expression and significance of HPV L1 capsid protein in squamous intraepithelial lesions of uterine cervix

人乳头状瘤病毒感染(Human papillomavirus,HPV)是宫颈癌发生的必要因素,L1蛋白是HPV的主要衣壳蛋白,是免疫反应攻击HPV病毒和病毒感染细胞的主要靶位,对HPV感染阶段的判定以及宫颈病变程度和结局的预测有重要意义。本文对HPVL1蛋白的结构作用、相关应用研究及临床应用价值进行了综述。

Human papilloma virus （HPV） was the main aetiological factor for cervical cancer, L1 protein was the main eapsid protein of HPV, and it was associated with immune responses to HPV and HPV - infected cells. The HPV L1 protein expression was closely related to spontaneous disease regression. In this article, the structure and function of HPV L1 protein and its application research and clinical value were reviewed.