水飞蓟素抗丙型肝炎病毒作用的研究进展

Developments in research of the anti-hepatitis C viral effects of silymarin

慢性丙型肝炎是严重的全球性卫生问题,其进展为肝硬化、肝癌的几率较高,目前缺乏新的、有效的、不良反应小的治疗手段。水飞蓟素是广泛应用于多类肝病的常用药物,其主要作用包括具有抗氧化、抗纤维化、抗炎、免疫调节以及促肝细胞再生作用。目前研究发现水飞蓟素具有抗丙型肝炎病毒的作用,其主要作用机制为直接抑制丙型肝炎病毒的作用及间接由NF-κB介导的抗炎、调节免疫作用。临床观察发现水飞蓟素静脉制剂其可以降低HCV-RNA水平,并可辅助增强干扰素抗病毒作用,但其是否可有效抗丙型肝炎病毒仍需大样本临床试验证实。

Chronic hepatitis C is a globally serious medical problem, which has more rapid progresses into cirrhosis and hepatocellulor carcinoma without effective and less toxic novel treatments. Silymarin has been used to treat a range of liver disorders, and its main effects include antioxidant, antifibrotic, anti-inflammatory, immumor- egulatory and hepatocellulor regeneration-promoting effects. Currently, investigators found that silymarin has anti- hepatitis C viral effects via indirectly inhibiting NK-KB-induced inflammation and immune responses, and direct an- tiviral effects against HCV infection. In some clinical trails, the intravenous formulation of silymarin has been found to decrease serum HCV-RNA titers and enhance IFN anti-HCV efficacy. Therefore, in the future, large scale clini- cal studies focusing on the antiviral effects of silymarin should be required.