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miRNA对骨质疏松症的调控 被引量：1

Regulation on miRNA to osteoporosis
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摘要 microRNA(miRNA)是一种内源性的单链非编码小RNA。通过与靶mRNA的3'UTR结合,参与调控约30%的基因表达,是重要的转录后水平调控因子。在细胞的增殖、分化、凋亡、代谢等生理过程中发挥广泛的作用。研究表明,miRNA与肿瘤、心脏病、糖尿病、帕金森综合症等多种复杂疾病的发生有关,且与多药耐药有关,本文将就miRNA对骨质疏松症的调控等作一综述。 miRNAs are endogenous non-cod- ing single stranded small RNA molecule and are predicted to regulate 30o//00 of all human genes by targeting mRNA sequences in their 3＂UTR. As important post transcriptional regulators, miR- NAs play a positive role in various biological processes, including proliferation, differentia- tion, apoptosis, metabolism, and so on. Recent studies have indicated that miRNAs are associat- ed with caner, cardiac disease, diabetes, Parkin- son syndrome and multidrug resistance. Herein the article reviews the regulation on miRNAs to osteoporosis.
作者 王萍 尹桃 周伯庭
机构地区 中南大学药学院 中南大学湘雅医院药剂科 中南大学临床药理研究所
出处 《中国临床药理学与治疗学》 CAS CSCD 2013年第1期110-114,共5页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 MIRNA 骨质疏松症 基因 miRNAs Osteoporosis Gene
分类号 R968 [医药卫生—药理学]
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参考文献42

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共引文献3

同被引文献14

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中国临床药理学与治疗学
2013年 第1期

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