功能性肠病患者小肠细菌过度生长及其预测因素分析

Frequency and predictors of small intestinal bacterial overgrowth in patients with functional bowel disorders

目的通过对功能性肠病(FBD)患者进行乳果糖氢呼气试验(LHBT)检测,初步探讨其小肠细菌过度生长(SIBO)的发生率及其预测因素。方法符合罗马Ⅲ诊断标准的94例FBD患者接受LHBT检测,并根据其结果将FBD患者分为LHBT阳性组和LHBT阴性组,调查其相关的危险因素。结果 94例FBD患者中,LHBT阳性率为32.98%,其中IBS患者LHBT阳性率为33.90%。LHBT阳性组和LHBT阴性组之间的腹胀程度(X2=10.984,p=0.012)、腹胀持续时间(X2=9.873,p=0.020)、抗生素使用时间(X2=10.287,p=0.016)的差异有统计学意义。经多因素Logistic回归分析腹胀持续时间是LHBT阳性的独立预测因子(OR=2.222,95%CI:0.547～9.023,p=0.016)。结论近1/3的FBD患者存在SIBO,腹胀持续时间是FBD合并SIBO的独立预测因子。

Objective To investigate the frequency and predictors of small intestinal bacterial overgrowth （SIBO） in patients with functional bowel disorders （FBD） by lactulose hydrogen breath test（LHBT）. Methods 94 patients with FBD met Rome m criteria were tested with LHBT, and then the clinical features were compared between the LHBT-positive and - negative group. Results 31 （32. 98% ） patients showed positive LHBTs in 94 FBD patients and 20 （33.90%） IBS patients had the same results. The severity （X^2 = 10. 984, p = 0. 012） , and the duration （X^2 = 9. 873, p =0. 020） of abdominal bloating, the proportion of antibiotics-consumption （X^2 = 10. 287 ,p =0. 016） were significantly different between the LHBT-positive and - negative FBD patients. However, Logistic regression analysis showed that only the duration of abdominal bloating is an independent predictive factor of positive-LHBT （OR = 2. 222, 95% CI： 0. 547 - 9. 023, p = 0. 016）. Conclusion SIBO are present in nearly one third of these FBD patients based on the resuits of LHBT, and the duration of abdominal bloating is an independent predictor of SIBO.