精囊蛋白Semenogelin Ⅰ小分子片段的功能

Activities of the fragments of Semenogelin Ⅰ:An update

Semenogelin Ⅰ及其被前列腺特异性抗原水解后的小片段肽具有多种生物学活性,其中抑制精子活力的关键小片段肽备受争议。本文主要对其抑制精子活性、抗菌活性等进行综述,并就目前争议较大之处提出猜想进行解释。深入研究这些肽的作用机制有助于改进人工受精筛选精子的方法,也可能为治疗弱精子症及泌尿系感染提供新的方向。

Semenogelin Ⅰ （Sg Ⅰ） and the fragments of peptides hydrolyzed from Sg I by prostate-specific antigen have multiple biological activities. There exists a controversy over the inhibitory effect of the key fragment on sperm motility. This article focuses on the sperm-inhibiting and antibacterial activities of the fragments of Sg I-derived peptides and illustrates the supposition concerning the most contr.bversial aspect. A deeper insight into the action meehanisms of Sg Ⅰ-derived peptides may help improve the methods of sperm screening and provide a new perspective in the management of asthenozoospermia and urinary tract infection.