人体左心室三维有限元模型构建及流-固耦合动力学分析

Fluid-Structure Interaction Analysis Based on a 3D Finite Element Model of Human Left Ventricular

有限元分析是研究心血管动力学问题的重要手段。本文基于中国数字人体心脏断层解剖图像,采用Visu-al C++可视化工具包对心脏外形及内腔结构进行三维重建,进一步基于结构模型构建了左心室、血液耦合有限元模型。在通用有限元分析软件ANSYS环境下使用双向流-固耦合方法对心脏灌注期心室壁受力与血液流动过程进行了动力学仿真。仿真结果成功实现了对心脏灌注期心室两阶段充盈过程中室壁应力与血液流体动态特性的定量分析。本研究提供了一种基于二维医学图像信息构建心室有限元模型,并进行心室血液流体力学模拟的新方法,为心脏生理及病理过程的定量有限元分析提供了一套可行的技术方案。

A 3D model of heart configurations and interior structures has been constructed using Visual C＋＋ visual- ization toolkit based on the Dataset of Visible Chinese Human. The finite element model of left ventricular is obtained from the heart structure model. Both ventricular wall and blood in the cavity are modeled by finite element mesh. The fluid-structure coupling of the left ventricle and blood has been constructed using an arbitrary Lagrange-Euler al- gorithm. Based on these models, the fluid-structure interaction of the left ventricle and blood in the filling phase is simulated. The simulation result successfully reproduced the biphasie filling flow consisting of early rapid filling and atrial contraction, which is similar to the clinical observation. This study provides a feasible method with which we can use image-based fluid-structure simulation to analyse the structure and haemodynamics properties of heart. It could be applied in heart functional investigations and clinical applications.