分化抑制因子Id-1与VEGF及MVD在宫颈癌变中的相关性分析

Correlation of inhibitor of differentiation 1 and VEGF and MVD in cervical cancer

目的:研究分化抑制因子-1(Id-1)与血管内皮生长因子(VEGF)及微血管密度(MVD)在宫颈组织癌变中的相关性,探讨Id-1在宫颈癌血管形成中的机理。方法:采用免疫组化法检测50例宫颈癌石蜡标本中Id-1、VEGF及CD34的表达;用CD34标记肿瘤微血管,计算MVD。结果:宫颈癌组织中Id-1、VEGF及MVD均呈高表达,且均与临床FIGO分期进展具有相关性(P<0.05)。宫颈癌组织中三者的表达具有显著正相关性(P<0.01),Id-1与VEGF、Id-1与MVD的spearman相关系数(Ra)分别为0.43,0.48。结论:宫颈癌组织中Id-1与VEGF、MVD的表达具有正相关性,Id-1可能是通过促进肿瘤微血管生成的机制参与宫颈癌的发生。

Objective：To study the correlation of inhibitor of differentiation 1（Id-1） and vascular endothelial growth factor（VEGF） and microvessel density（MVD）,and discuss microvessel angiogenesis in cervical cancer.Methods：Id-1,VEGF and CD34 were detected in 50 tissues of cervical cancer by immunohistochemical method,CD34 was used to mark the microvessels and calculate MVD.Result：Id-1,VEGF and MVD were expressed highly in cervical cancer and correlated to the International Federation of Gynecology and Obstetrics（FIGO） clinical stages,respectively（P0.05）.Id-1 expression also had positive correlation with expressions of VEGF and MVD in cervical cancer tissues（P0.01,respectively）.Spearman coefficients（Ra） was 0.43 and 0.48.Conclusion：Id-1 may promote tumor formation through the mechanism of promting microvessel angiogenesis of tumor in cervical cancer development.