摘要
Esophageal squamous cell carcinoma(ESCC) is a prevalent and fatal cancer in China and other Asian countries.Epigenetic silencing of key tumor suppressor genes(TSGs) is critical to ESCC initiation and progression.Recently,many novel TSGs silenced by promoter methylation have been identified in ESCC,and these genes further serve as potential tumor markers for high-risk group stratification,early detection,and prognosis prediction.This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC,providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.
Esophageal squamous cell carcinoma （ESCC） is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes （TSGs） is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.
基金
supported by NSFC Joint Research Fund for Hong Kong and Macao Young Scholars(No.30928012)
National Natural Science Foundation of China(No.81071634,81172582,and 30801344)
Shenzhen Science Fund for Distinguished Young Scholars(No.JC201005270328A)
