鼻咽癌中EphrinB2与VEGF的表达及临床意义

The expressions of EphrinB2 and VEGF in nasopharyngeal carcinoma and their clinical significance

目的:研究EphrinB2与血管内皮生长因子(VEGF)在鼻咽癌组织中的表达情况及其与各临床病理因素之间的关系。方法:应用免疫组织化学SP法检测136例鼻咽癌组织标本及20例鼻咽黏膜慢性炎症组织中EphrinB2与VEGF的表达情况。结果:①136例鼻咽癌组织中EphrinB2与VEGF阳性率分别为63.2%和67.6%,二者的阳性表达均明显高于鼻咽黏膜慢性炎症组织(P<0.01);②EphrinB2和VEGF蛋白的阳性表达分别与淋巴结转移、脑神经麻痹、颅底侵犯和临床分期相关(P<0.01);③在鼻咽癌组织中EphrinB2的表达与VEGF的表达显著相关(P<0.01)。结论:EphrinB2和VEGF可能在鼻咽癌的浸润、转移和血管生成中起重要作用,它们之间可能存在一定的相互调控机制,它们有望成为判断鼻咽癌发生、发展、预后及指导治疗的新的生物学指标。

Objective：To investigate the expressions of EphrinB2 and VEGF in nasopharyngeal carcinoma and their relationships with clinic pathological factors.Method：The expressions of EphrinB2 and VEGF in 136 cases of nasopharyngeal carcinomas,and 20 cases of nasopharyngitis tissues were detected by SP method immunohistochemistry.Result：①The positive rates of EphrinB2 and VEGF were 63.2% and 67.6% respectively in 136 cases of nasopharyngeal carcinomas.Their positive rate in nasopharyneal carcinoma tissues was significantly higer than those in nasopharyngitis tissues（P0.01）.②Iniensity of the expression of EphrinB2 and VEGF protein was related to lymphnodes metabasis,cranial nerve palsy,basalis encroachment,clinical stage respectively（P0.01）.③The expression of EphrinB2 in nasopharyngeal carcinoma tissues and was positively correlated with VEGF（P0.01）.Conclusion：Ephrinβ2 and VEGF may play important roles in invasiveness,metastasis and angiogenesis of nasopharyngeal carcinoma.There may be certain interregulation mechanism between them and they are hoped to become new biologic parameters to judge the pathogenesis,development and prognosis of nasopharyngeal carcinoma and to guide the treatment.