摘要
目的:观察结缔组织生长因子(CTGF)在非小细胞肺癌(NSCLC)组织和正常肺组织中表达的差异性,并初步探讨CTGF表达与NSCLC恶性程度、侵袭和转移的关系。方法:采用免疫组织化学法(S-P法)检测50例NSCLC和10例正常肺组织中CTGF的表达情况,并分析CTGF与NSCLC患者临床病理特征之间的关系,以及CTGF在NSCLC组织中表达的相关性。结果:在50例NSCLC组织中有15例(30%)CTGF呈阳性表达,10例正常肺组织中有9例为阳性表达;统计结果显示,CTGF表达与NSCLC的临床分期(P=0.005)、淋巴结转移(P=0.04)有相关性。结论:CTGF在NSCLC组织中的表达较正常肺组织明显下调,与NSCLC的临床分期和淋巴结转移有相关性,提示CTG可能与NSCLC的侵润和转移有关。
bjective To detect the expression levels of CTGF in human non-small cell lung cancer（NSCLC） and normal lung tissue, and to estimate whether it can be a indicator of invision and metastasis in human NSCLC. Mthods The expression of CTGF was assessed by immunohistochemical staining in 50 paraffin-embedded NSCLC specimens and 10 specimens of normal lung tissue that came from the department of Thoracic Surgery. Results In the immunoreactive cells, staining of CTGF was mainly located in cytoplasma. The expression of CTGF in human NSCLC was 30%, while highly expressed in epithelia of lung benign lesion tissues. The expression of CTGF significantly correlated with TNM stage （P=0.005） and lymphatic metastasis （P=0.04）. While in multivariate analysis, theexpression of CTGF could be considered as one of risks in angiogenesis and metastases factors. Conclusion CTGF might play important roles in the development, invasion and metastasis of NSCLC.
出处
《药品评价》
CAS
2012年第33期38-41,共4页
Drug Evaluation
