龙须藤提取物的镇痛抗炎作用

Study on the anti-inflammatory and analgesic effects of Bauhinia championii Benth extract in mice

目的研究龙须藤乙醇提取物的镇痛抗炎作用,筛选出龙须藤镇痛抗炎作用的有效部位。方法采用热板法和冰乙酸扭体法观察镇痛作用,采用二甲苯致小鼠耳郭肿胀法观察抗炎作用。结果龙须藤醇提物具有较好的镇痛抗炎作用;龙须藤醇提物的乙酸乙酯萃取物和正丁醇萃取物具有显著的镇痛作用,并能较好抑制炎症的组织液渗出。结论龙须藤醇提物的乙酸乙酯部位和正丁醇部位可能是龙须藤镇痛抗炎作用的有效部位。

Objective To study the anti-inflammatory and analgesic effects of Bauhinia championii Benth extract in mice,and screen out its effective fractions.Methods Two models that hot plate and writhing test caused by glacial acetic acid in mice were used to observe the anti-inflammatory effect.The model that ear swelling caused by dimethyl benzene in mice was adopted to observe the analgesic effect.Results The ethanol extract from Bauhinia championii Benth obviously showed anti-inflammatory and analgesic effects.Ethyl acetate extract and n-butanol extract exhibited anti-inflammatory effect,and inhibited effusion of tissue fluid caused by inflammation.Conclusion Ethyl acetate extract and n-butanol extract may be the effective parts of Bauhinia championii Benth for the anti-inflammatory and analgesic effects.