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羟基酪醇药理作用研究进展 被引量：13

Research progress on pharmacological actions of hydroxytyrosol
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摘要 羟基酪醇(Hydroxytyrosol,HT)化学名3,4-二羟基苯乙醇,具有很强的抗氧化活性,主要以酯类的形式存在于橄榄的果实和枝叶中。HT具有多方面的生物活性。本文就近年来国内外对羟基酪醇在抗癌、抗血栓、调血脂和抗动脉硬化、抗病原微生物、防治视网膜黄斑变性、保护软骨和抗骨质疏松及其他保健作用等方面的药理作用及其机制研究进行综述。 The Hydroxytyrosol′s chemical name is 3,4-Dihydroxyphenylethanol which mainly presents in olives leaves and fruits as esters and it provides an exceptional antioxidative activity.The Hydroxytyrosol has many biological activities.Combined with domestic and foreign research,its pharmacological activity and mechanism will be introduced in this paper,including anti-cancer,anti-cardiovascular diseases,anti-microbial,protecting retinal pigment epithelial cells,anti-osteoporosis and so on.
作者 刘威振 张兴 陈新建 谭毓治
机构地区 广东药学院药科学院
出处 《广东药学院学报》 CAS 2012年第6期684-688,共5页 Academic Journal of Guangdong College of Pharmacy
关键词 羟基酪醇 药理作用 抗癌 抗心血管疾病 抗菌 hydroxytyrosol pharmacological activity anti-cancer anti-cardiovascular diseases anti-bacterial
分类号 R285 [医药卫生—中药学]
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参考文献42

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同被引文献109

  • 1陆露,毛家亮,赵焕昌,沈心逸.抗焦虑抑郁药物治疗对心绞痛伴心理障碍患者再发病及再入院的影响[J].中国全科医学,2013,16(27):3176-3178. 被引量：17
  • 2陈春富,宋振海.神经系统疾病动物模型[M].长春:吉林科学技术出版社,2007:245-246.
  • 3GRANADOS-PRINCIPAL S,QUILES J L, RAM1REZ-TORTOSA C L, et al. Hydroxytyrosol: From laboratory investigations to future clinical trims [ J ]. Nutrition Reviews,2010,68 (4) : 191-206.
  • 4VISIOLI F,CARUSO D, PLASMATI E, et al. Hydroxytyrosol, as a component of olive mill waste water, is dose-dependently absorbed and increases the antioxidant capacity of rat plasma[ J ]. Free Radical Research ,2001,34 (3) :301-305.
  • 5BISIGNANO G, TOMAINO A, CASCIO R L, et al. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol [ J ]. Journal of Pharmacy and Pharmacology, 1999,51 ( 8 ) :971-974.
  • 6KILLEEN M J, PONTONIERE P, CREA R. Hydroxytyrosol:An examination of its potential role in cardiovascular disease, inflammation, and longevity [ J ]. Agricultural Food Industry High Technology,2011,22 ( 5 ) : 16-19.
  • 7OWEN R W, GIACOSA A, HULL W E, et al. The antioxidant/anticaneer potential of phenolic compounds isolated from olive oil[ J ]. European Journal of Cancer.2000.36(10) :1235-1247.
  • 8FABIANI R, BARTOLOMEO D A, ROSIGNOLI P, et al. Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells ( HL60 ) by inducing apoptosis and differentiation [ J ]. The Journal of Nutrition, 2006,136 ( 3 ) : 614-619.
  • 9BERNINI R, CRISANTE 17, MERENDINO N, et al. Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 ceils[ J ]. European Journal of Medicinal Chemistry ,2011,46 ( 1 ) :439-446.
  • 10BOUALLAGUI Z, HAN J, ISODA H, et al. Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells [ J ]. Food and Chemical Toxicology,2011,49 ( 1 ) : 179 - 184.

引证文献13

二级引证文献54

广东药学院学报
2012年 第6期

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