煤烘玉米和饮水为介质地氟病区骨畸形病人全血尿多元素含量的分析

Analysis of Poly-elements in Blood and Urine of Bone-deformed Patients from Endemic Fluorosis Area of Different Vector Types

采集了贵州 4个煤烘玉米为主要介质和河北 2个饮水为介质氟病区内骨畸形病人的全血、尿 ,检测了其中 8种元素含量。结果表明 ,贵州各氟病区少儿骨软化与成年骨硬化畸形病人的全血铝、钙、磷、铁和尿氟、铝均显著高于同龄对照组 ,尿磷均低于同龄对照组。少儿骨软化病人全血锌均下降 ,尿锌多下降。某水型氟病区骨软化经产妇尿氟、全血铜升高 ;骨软化少年全血铝显著升高 ,锌、铁下降 ,尿氟升高 ,尿锌、磷下降。海边的典型氟骨症病人全血、尿元素均显著增高。表明地氟重病区普遍有铝氟联合作用的危害 ,骨效应在少年儿童主要为铝危害的骨矿化不足的软化畸形 ,成年人已转换为氟中毒为主的骨关节及骨周骨化的矿化过度的硬化性畸形。水型氟病区骨软化少儿也受到铝的危害。

To test the content of 8 elements, blood and urine of bone-deformed patients from endemic fluorosis area of 4 coal-dried-corn vector in Guizhou and 2 drinking water vector were determined. The X-ray diagnosis showed that childien were osteomalacia and adults were osteoselerotic deformity. In each fluorosis area in Guizhou, contrasted with the same aged control group, Al,Ca,P,Fe in blood. F and Al in urine of the osteomalacia children and the osteoselerotic deforned adults were markedly higher, but P in urine were lower. For osteomalacia children patients, Zn in blood decreased in all patients while Zn in urine decreased for most of them. In water type fluorosis areas, F in urine and Cu in blood of osteomalacia puerperous women increased, in osteomalacia children. Al in blood increased significantly. Zn and Fe in blood decreased, F in urine increased, Zn and P in urine decreased. The element content in blood and urine increased markedly for the typical fluorosis bone patients by the seaside. It indicated that there exists commonly Al-F united damage in the serious endemic fluorosis area, for the young people, the main effect on bone was less ossifying osteomalacia deformity caused by Al for the adults.It had turned to over ossifying osteoselerotic deformity around the bone caused by fluorosis in water type fluorosis areas, there also exists Al damage to the children suffering from osteomalacia.