基于2%莫匹罗星软膏治细菌感染性皮肤病作用观察2%夫西地酸乳膏的疗效及安全性

Safety and Cure Effect of 2% Fusidic Acid Cream on Bacterium-infected Skin Disease

[目的]观察2%夫西地酸乳膏(fusidic acid cream,FAC)治疗细菌感染性皮肤病的疗效和安全性。[方法]设计采用2%FAC治疗为治疗组,采用2%莫匹罗星软膏(Mupirocin ointment,MO)治疗为对照组;研究病例选择按照两组患者在性别、年龄、皮肤病各类上差异无统计学意义(P>0.05)为前提,在2011年1月至2011年12月来我院就诊并被确诊为细菌感染性皮肤病的病例资料里选出82例患者分为两组(治疗组、对照组各41例);疗程结束后,观察两组疗效和安全性。[结果]两组治疗后按皮损面积与严重程度指数(Eczema area severity index,EASI)评分并予比较,差异有统计学意义(P<0.05)。治疗组治疗后有效35例,总有效率35/41(85.37%),对照组有效36例,有效率36/41(87.8%),两组比较差异无统计学意义(P>0.05)。治疗组未发现明显不良反应病例,对照组有1例患者出现中度瘙痒,未经任何处理,自行缓解,发生率为1/41(2.44%),两组比较差异无统计学意义(P>0.05)。[结论]2%FAC治疗细菌感染性皮肤病的疗效确切,安全性高,可在临床推广应用。

[Objective] To study the safety and effect of 2% Fusidic Acid Cream on bacterium infected skin disease.[Method] The design takes 2% Fusidic Acid Cream therapy as treatment group,2% Mupirocin Ointment as control group;the cases selection has no difference of statistical meaning on sex,age and skin disease types.Choose 82 cases and divide them into 2 groups,41 cases in each one.After treating course,observe their cure effect and safety.[Result] Compare both EAST scores,with statistical meaning for difference.In treatment group,35 cases are effective,the total effective rate is 35/41（85.37%）;for control one,they are 36 and 36/41（87.8%） respectively;the difference of comparison has no statistical meaning.There＇s no marked side effects in treatment group,but in control one,1 case has moderate pruritus,which is relieved without treatment,the rate is 1/41（2.44%）,the comparison has no statistical meaning.[Conclusion] 2% Fusidic Acid Cream has definite cure effect in treating bacterium infected skin disease,with high safety,worthy clinical promotion.