摘要
目的:将肝癌患者分为介入治疗(TACE)和介入加放疗(TCR)2组,用倾向指数匹配法均衡组间的协变量,评价2种治疗方式的效果。方法:采用logistic回归模型计算肝癌患者的倾向指数,然后按照倾向指数进行组间卡钳匹配,对匹配后的数据进行生存分析。结果:匹配前2组的生存率差异无统计学意义,Log-Rank检验的χ2=1.792,P=0.181;匹配后差异有统计学意义,Log-Rank检验的χ2=4.026,P=0.045。结论:采用倾向指数匹配法能有效降低混杂偏倚,对肝癌患者的治疗效果做出正确评价。
Aim:To evaluate the effects of transcatheter arterial chemoembolization(TACE)combined with or without radiation therapy on two groups of hepatocellular carcinoma(HCC) patients after balancing the covariates by propensity score.Methods:Each patient's propensity score from the model was calculated and made caliper matching according to the propensity score.And then make survival analysis for the matched data.Results:There were no significant differences in the survival rate between the 2 groups before matching,with χ2 of 1.792 and P of 0.181 from Log-Rank test.But the differences in the survival rate were statistically significant between the 2 groups after matching,with χ2 of 4.026 and P of 0.045 from Log-Rank test.Conclusion:Propensity score matching method can effectively reduce the confounding bias of non-randomized clinical observational data,helping us evaluate the curative effect of HCC patients correctly.
出处
《郑州大学学报(医学版)》
CAS
北大核心
2012年第6期769-772,共4页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金资助项目81141112
山东省自然基金资助项目ZR2009CM117
关键词
倾向指数
匹配法
肝癌
生存分析
propensity score
matching method
hepatocellular carcinoma
survival analysis