甘露聚糖肽皮试液浓度的临床观察与探讨

The Clinical Observation and Study on the Skin Allergy Test Solution of Mannatide

目的:探讨甘露聚糖肽皮试溶液的最适宜浓度。方法:对753例住院患者,采用单盲随机对照法,使用三种浓度的皮试液进行皮内注射,随后,高浓度、中浓度皮试阳性者再用低浓度做皮试。结果:高浓度、中浓度、低浓度皮试溶液皮试结果配对比较,两两之间均存在显著性差异(P<0.01),高浓度、中浓度皮试阳性者再用低浓度做皮试,其假阳性率分别为20.72%、5.58%,且经低浓度筛选出的阴性患者,静脉滴注后,无一例发生速发型变态反应。结论:科学、准确的甘露聚糖肽皮溶液试浓度有利于降低皮试结果的假阳性率,将甘露聚糖肽注射液稀释100倍进行皮试,安全可靠,为较佳的甘露聚糖肽皮试液。

Objective：To explore the most suitable mannantide solution for skin allergy test.Methods：753 hospitalized patients were divided into the high skin test concentration group（n=251）、moderate skin test concentration group（n=251） and low skin test concentration group（n=251） by single-blind randomized controlled clinical trial.3 different concentrations of the skin test were used for intra-injection.Subsequently,positive skin test patients in high concentration group and moderate skin test concentration group were intra-injection by the low skin test.Results：There were significant differences among the three groups with skin test results（P0.01）.The false positive rate of the high concentration group and moderate skin test concentration group were 20.72% and 5.58%,none of the negative patients selected by the low skin test occurred Immediate allergic reaction in the process of infusion.Conclusion：Science,accurate mannatide skin test are favorable to reduce the rate of false positive skin test.As skin test,mannatide injection diluted to 100 times was safe,reliable which can maximum screen allergic patients.