酚妥拉明联合盐酸氨溴索治疗小儿重症肺炎观察

Cincal Observation of Phentolamine Combined with Ambroxol Hydrochloride in Treating Svere Mycoplasma Pneumoniae Pneumonia in Children

目的:探讨酚妥拉明联合盐酸氨溴索治疗小儿重症肺炎的临床疗效。方法:选择2010年1月-2012年4月本院儿科收治的重症肺炎患儿94例,按照随机数字表法分为观察组和对照组,每组各47例。两组患儿均接受常规对症和抗感染治疗,观察组在此基础上静脉滴注酚妥拉明5μg/(kg.min),每次1h,每日2次,同时给予盐酸氨溴索7.5-15mg/次,每日2次,7d为1个疗程。并对两组患儿咳嗽、哮鸣音、湿啰音等临床症状消失时间,以及临床疗效进行比较。结果:观察组患儿治疗总有效率达93.6%,显著高于对照组,且观察组住院时间仅为(9.8 3.0)d,退热、心衰纠正和各项临床症状改善时间均显著低于观察组(P<0.05)。结论:酚妥拉明联合盐酸氨溴索能够显著降低缩短临床症状及体征消失时间,且大大提高临床疗效,值得临床推广。

Objective：To investigate the clinical effect of phentolamine combined with ambroxol hydrochloride in treating svere mycoplasma pneumonia in children.Methods：94 children with svere mycoplasma pneumonia were selected and divided into two groups randomly and for each 47.All the children were given common symptomatic and anti-infection treatment,and children in observation group were given phentolamine 5μg/（kg·min） by intravenous infusion,each time for 1h and twice per day,combined with ambroxol hydrochloride with dose of 7.5-15mg per time and twice per day,7 days for a course.Results：The hospital time and total efficiency of observation group was 9.8±3.0d and 93.6%,and all the time of clinical improvement were significantly better than that of control group （P0.05）.Conclusion：Phentolamine combined with ambroxol hydrochloride in treating svere mycoplasma pneumonia in children has a good efficiency and significantly lower the time of symptoms and signs disappeared,and deserve to clinical.