FPSA、TPSA及FPSA/TPSA比值在前列腺癌诊断中的临床意义

Clinical significance of FPSA,TPSA and ratio of FPSA/TPSA in diagnosis of prostate cancer

目的探讨FPSA、TPSA及FPSA/TPSA比值在前列腺癌(PCa)诊断的应用价值。方法采用电化学发光法测定134例,其中PCa 34例,前列腺增生(BPH)100例与正常健康体检男性的血清FPSA、TPSA水平,计算FPSA/TPSA比值。结果 PCa组FPSA、TPSA的水平明显高于BPH组和正常对照组(P均<0.01);PCa组FPSA/TPSA比值明显低于BPH组和正常对照组(P均<0.01)。当FPSA/TPSA<0.15,则PCa的可能性较大(PCa占93.3%),而FPSA/TPSA>0.30时,则PCa的可能性较小(PCa占5.9%)。结论联检FPSA、TPSA及FPSA/TPSA是提高前列腺疾病诊断与鉴别诊断的有效方法,尤其对PCa诊断更为有临床意义。

Objective To investigate the diagnostic value of the FPSA,TPSA and the ratio of FPSA/TPSA in prostate cancer（PCa）.Methods The serum FPSA and TPSA levels of 134 patients（34 patients with PCa,100 patients with BPH） and 40 healthy men as normal control were determined by electrochemical luminescence,and the ratio of FPSA/TPSA was calculated.Results FPSA and TPSA of PCa was significantly higher than of BPH and normal control（P0.01）.The ratio of FPSA/TPSA in PCa was significantly lower than of BPH and normal control（P0.01）.When the FPSA/TPSA0.15,PCa probability was 93.3%,and FPSA/TPSA0.30,PCa were less likely to 5.9%.Conclusions The FPSA,TPSA and FPSA/TPSA are to improve diagnosis and differential diagnosis of prostatic diseases,especially for the diagnosis of PCa has more clinical significance.