皮质抑素在内分泌系统中的作用

Role of Cortistatin in the Endocrine System

皮质抑素(cortistatin,CST)是一种新型神经内分泌肽,因其在皮质中大量表达并抑制皮质的功能而得名,属于生长抑素基因家族新成员,与生长抑素(somatostatin)具有结构同源性.CST能与生长抑素受体、生长素释放肽受体、Mas相关基因2受体结合,发挥多种生物学效应,如诱导慢波睡眠、参与炎症过程、调节神经内分泌.研究表明,就内分泌系统而言,CST是生长抑素的一种天然替代物.本文重点从细胞、整体水平对CST在内分泌系统中的作用做一简介.

Cortistatin （CST） is a novel neuropeptide of the somatostatin homologous family which is mainly expressed in cortex and able to suppress the cortical activities. CST binds to somatostatin receptor, ghrelin receptor, or Mas-related gene X2 receptor, thus to mediate various biological effects, such as the induction of slow-wave sleep, participation of inflammation and the regulation of neuroendocrine functions. Studies suggested that CST might be considered a natural alternative of somatostatin with endocrine properties. In this review, we summarized the findings that demonstrated CST functions in endocrine system at cellular or whole body levels.