DWI观察乳猪腮腺放射治疗后ADC值变化与病理的相关性

Correlation between ADC and pathologic findings of parotid gland radiation injury of miniature pigs with diffusion weighted imaging

目的分析乳猪腮腺放射治疗前、后的ADC值和病理变化及其相互关系,探讨DWI诊断乳猪腮腺放射性损伤的价值。方法对8只乳猪行单剂量放疗,放疗前、后行常规MR和DWI检查,测量左、右侧腮腺的ADC值,记录放疗前、后腮腺组织的病理改变。结果放疗前乳猪左、右侧腮腺的唾液流速和ADC值差异无统计学意义(P>0.05);放疗后左、右侧腮腺的唾液流速和ADC值均有不同程度下降(P均<0.05)。ADC值与腮腺病理等级具有相关性(rs=0.649,P<0.05)。结论通过测量ADC值,DWI可能为腮腺放射性损伤提供一种无创的监测手段。

Objective To observe the diagnostic value of DWI for parotid gland radiation injury in miniature pig by analyzing ADC and pathology changes before and after radiation therapy as well as correlation between them. Methods Eight miniature pigs underwent single dose radiation. Conventional MR and DWI were performed before and after radiation therapy. The pathological changes and ADC values of left and right pig parotid gland were recorded before and after radiation. Results There was no difference of salivary flow rates and ADC values between left and right parotid gland before radiation（P〉0.05）. The flow rate and ADC value of left and right parotid gland decreased after radiation （both P〈0.05）. There was correlation between ADC values and pathological classification （rs=0.649, P〈0.05）. Conclusion DWI may be a non-invasive method to survey parotid gland radio-sensitivity by measurement of ADC values.