高频超声检测2型糖尿病周围神经病变患者足部肌肉萎缩

Detecting foot muscles atrophy in patients of type 2 diabetes mellitus with diabetic peripheral neuropathy by using high-frequency ultrasonography

目的探讨高频超声技术对2型糖尿病(T2DM)及合并周围神经病变(DPN)患者足部肌肉萎缩的诊断价值。方法收集106例T2DM患者,分为两组:A组56例,为T2DM伴DPN患者,B组50例,为T2DM不伴DPN患者;另选同期50名健康志愿者作为对照(C组)。应用高频超声观察受试者非优势足趾短伸肌(EDB)和第一、二跖趾间肌群(MIL),测量EDB横径、厚度和横截面积以及MIL厚度。结果 A组EDB横径、厚度和横截面积及MIL厚度均显著小于B组和C组(P均<0.01);B组EDB横径和横截面积及MIL厚度显著小于C组(P均<0.01)。结论高频超声技术能够客观评价T2DM及合并DPN患者足部肌肉萎缩。

Objective To explore the value of high-frequency ultrasonography in detecting foot muscles atrophy in patients of type 2 diabetes （T2DM） with or without diabetic peripheral neuropathy （DPN）. Methods One hundred and six T2DM patients were collected and divided into group A （T2DM with DPN, n=56） and B （T2DM without DPN, n=50）, and 50 healthy subjects were enrolled as control （group C）. The non-dominant foot were examined with high-frequency ultrasonography. The transverse diameter, thickness and cross-sectional area of the extensor digitorum brevis （EDB） muscle and thickness of muscles between the first and second metatarsal bone （MIL） were measured. Results The transverse diameter, thickness and cross-sectional area of EDB and thickness of MIL in group A were significantly smaller than those in group B and C （all P〈0.01）. The transverse diameter and cross-sectional area of EDB and thickness of MIL in group B were significantly smaller than those in group C （all P〈0.01）. Conclusion The foot muscles atrophy of T2DM patients with or without DPN can be detected with high-frequency ultrasonography objectively.