肝动脉化疗栓塞术联合热疗及三维适形放疗对原发性肝癌的临床疗效分析

Analysis on clinical effects of transcatheter arterial chemoembolization combined with hyperthermia and three-dimensional conformal radiotherapy on primary liver cancer

目的探讨肝动脉化疗栓塞术(TACE)联合体外微波热疗和三维适形放疗(3D-CRT)对原发性肝癌的临床疗效。方法将76例原发性肝癌患者随机分为2组:治疗组39例,接受TACE+3D-CRT+体外微波热疗;对照组37例,接受TACE+体外微波热疗。比较2组患者近期疗效、生存率及毒副反应的差异。结果治疗组有效率以及1、2年生存率显著高于对照组,2组毒副反应无显著差异。结论对于中晚期原发性肝癌患者,TACE联合体外微波热疗以及3D-CRT可明显提高疗效,且毒副作用可耐受。

Objective To observe the clinical effect of transcatheter arterial chemo-em- bolization （TACE） combined with extracorporeal microwave hyperthermia and three-dimensional conformal radiotherapy （3D-CRT） on primary liver cancer. Methods Seventy-six patients with pri- mary liver cancer were randomly divided into two groups. The treatment group （ n = 39） received TACE ＋ 3D-CRT ＋ extracorporeal microwave hyperthermia, while the control group （ n -- 37） re- ceived TACE ＋ extracorporeal microwave hyperthermia. The short-term effect, survival rate and toxic and side effects in two groups were compared. Results The efficacy rate, one-and two-year survival rates in the treatment group were obviously higher than those in the control group. There were no differences on the toxic and side effects between both groups. Conclusion For patients with middle-advanced primary liver cancer, TACE combined with extracorporeal microwave hyper- thermia and 3D-CRT can obviously improve the curative effect, and the toxic and side effects can be tolerated.