盐酸米诺环素辅助基础治疗对牙周炎患者肿瘤坏死因子-α的影响

Influence of periocline-assisted basic treatment on expression of tumor necrosis factor-α in periodontitis patients

目的观察盐酸米诺环素(派力奥)辅助牙周基础治疗对慢性牙周炎患者血清肿瘤坏死因子-α(TNF-α)的影响。方法将30例中、重度慢性牙周炎患者随机分为2组,A组接受派力奥辅助牙周基础治疗,B组只接受牙周基础治疗。治疗前和治疗结束后16周分别测量牙周探诊深度(PD)和血清TNF-α水平。结果与对照组比较,试验组PD和血清TNF-α水平降低更为显著,2组间差异有统计学意义(P<0.05)。结论派力奥辅助牙周基础治疗能显著降低慢性牙周炎患者血清TNF-α水平,并改善其牙周临床指数。

Objective To observe the influence of periodontal basic treatment with minocy- cline hydrochloride ointment （MHO, Periocline） as an adjuvant on expression of serum tumor necrosis factor （TNF）-α in chronic periodontitis patients. Methods Thirty patients with moderate to severe chronic periodontitis were randomly divided into experimental group and control group. The experimental group received periodontal basic treatment plus MHO as an adjuvant and the con- trol group received periodontal basic therapy alone. Periodontal probing depth （PD） and serum TNF-α were measured before treatment and 16th weeks after treatment. Results Compared with the control group, the experimental group showed a more significant decline of PD and serum TNF-α level with a statistically significant difference between the two groups （P 〈 0.05）. Conclusion Pe- riodontal basic treatment assisted with MHO can significantly reduce serum TNF-α level and im- prove their clinical indexes in chronic periodontitis patients.