米力农联合利尿剂对顽固性心力衰竭患者超声心动图及脑钠肽的影响

Influences of milrinone combined with diuretics on the echocardiography and brain natriuretic peptide of patients with refractory heart failure

目的观察米力农联合利尿剂治疗顽固性心力衰竭的疗效及安全性。方法顽固性心衰患者103例,采用自身前后对照法,在常规方法治疗无效后,予米力农治疗,并联合使用呋塞米等利尿剂。观察治疗前后症状、体征、血压、心率、脑钠肽(BNP),心脏超声参数及心功能指标。结果应用米力农及利尿剂后显效33例,有效61例,无效9例,总有效率为91.3%。米力农明显改善左室收缩功能障碍,对血压心率无明显影响。结论米力农联合利尿剂治疗能有效改善顽固性心衰的心功能。少见明显不良反应。

Objective To observe the therapeutic effect and safety of milrinone combined with diuretics in the treatment of refractory heart failure. Methods Self before-after control method was administered in 103 patients with refractory heart failure. When routine treatment had no effects, milrinone combined with diuretics like furosemide was given. The symptoms, signs, blood pressure, heart rate, brain natriuretic peptide （BNP）, cardiac ultrasound parameters and car- diac function indexes before and after treatment were observed. Results After the application of milrinone and diuretics, 33 cases were markedly effective, 61 cases effective, 9 cases non-effective, and the total efficacy rate was 91.3 %. Milrinone significantly improved left ventricular systolic dys- function, and had no conspicuous effect on blood pressure and heart rate. Conclusion Milrinone combined with diuretics can effectively enhance the heart function of refractory heart failure, with rarely-seen obvious adverse reactions.