氟桂利嗪预防脑梗死再发298例临床研究

Clinical study of flunarizine for preventing the recurrence of cerebral infarction in 298 patients

目的探讨加用氟桂利嗪预防脑梗死再发的临床效果。方法 298例脑梗死患者随机分为2组,均给予相同的基础治疗。观察组(n=150)再给予阿司匹林及盐酸氟桂利嗪;对照组则单用阿司匹林。比较治疗6个月后2组的总体疗效、血液流变学指标、不良反应及1年内的再发率。结果治疗6个月时观察组显效率显著高于对照组;观察组1年内脑梗死再发率明显低于对照组;2组患者治疗后血液流变学各项指标均较治疗前显著改善,而观察组改善情况显著优于对照组。随访1年,观察组不良反应发生率为11.3%,继续用药后逐渐消失。结论加用氟桂利嗪能显著降低脑梗死再发率,且不良反应轻微,值得推广。

Objective To explore the the recurrence of cerebral infarction. Methods clinical effect of the added flunarizine for preventing A total of 298 patients with cerebral infarction were divided into 2 groups randomly, and were given the same basic treatment. Aspirin and flunarizine were then added in observation group （n = 50） while single aspirin added in control group. Six months after treatment, the total therapeutic effects, hemorheology indexes, adverse reactions and reoccurrence rate within 1 year of two groups were compared. Results After 6 - month treatment, the marked efficacy in the observation group was obviously higher than that in the control group. The reoccurrence rate of cerebral infarction within 1 year in the observation group was obviously lower than that in the control group. After treatment, various hemorheology indexes obviously im- proved in both groups, while the improving condition in the observation group was superior to that in the control group. With 1 - year follow- up, the incidence rate of adverse reactions was 11.3 %, and the reactions gradually disappeared after continuous administration. Conclusion The added flu- narizine can conspicuously prevent the reoccurrence of cerebral infarction with slight adverse reac- tions. It＇s worthy of popularization.