美他多辛联合多烯磷脂酰胆碱治疗酒精性肝病临床疗效观察

Observation on the clinical effect of metadoxine combined with polyene phosphatidylcholine for alcoholic liver disease

目的探讨美他多辛联合多烯磷脂酰胆碱治疗酒精性肝病的临床疗效。方法 60例酒精性肝病(ALD)患者随机分为治疗组和对照组,每组30例。对照组在一般治疗基础上给予多烯磷脂酰胆碱;治疗组在对照组基础上给予美他多辛;疗程均为4周。检测2组治疗前后血清谷丙转氨酶(ALT),谷草转氨酶(AST),胆红素(TBil),谷酰转肽酶(GGT)水平,比较2组治疗后症状、体征改善情况和临床有效率。结果 2组治疗后血清ALT、AST、TBil、GGT水平均明显降低。治疗组治疗后血清ALT、AST、TBil、GGT水平明显低于对照组。2组治疗后症状、体征改善情况无显著差异。治疗组临床有效率明显高于对照组。结论美他多辛和多烯磷脂酰胆碱联用治疗酒精性肝病,疗效优于单用多烯磷脂酰胆碱。

Objective To explore the clinical effect of metadoxine combined with polyene phosphatidyl choline in the treatment of alcoholic liver disease. Methods Sixty patients with alco- holic liver disease （ALD） were randomly divided into treatment group and control group, 30 cases in each group. The control group received polyene phosphatidylcholine on the basis of general treat- ment. The treatment group received metadoxine on the basis of the control group. The courses of treatment of both groups were 4 weeks. The levels of serum alanine aminotransferase （ALT）, as- partate aminotransferase （AST） total, bilirubin （TBil） and gamma-glutamyl transpeptidase （GGT） of two groups before and after treatment were detected. The symptoms, signs and clinical efficiency of two groups after treatment were compared. Results After treatment, the levels of ALT, AST, TBil and GGT in serum significantly reduced in two groups. After treatment, the levels of ALT, AST, TBil and GGT in serum of the treatment group were markedly lower than that of the control group. The improved conditions of symptoms and signs had no significant differences between two groups after treatment. The clinical efficacy rate of the treatment group was significantly higher than that of the control group. Conclusion The therapeutic effect of metadoxine combined with polyene phosphatidyl choline are superior to that of polyene phosphatidyl choline in the treatment of alcoholic liver disease.