联合检测Fib、D-D、FDP和β2-MG对肺癌的诊断价值

Study on significance of combined detection of four bio-markers in diagnosis of lung cancer

目的探讨4种生物标志物在肺癌辅助诊断中的应用价值。方法分别应用凝固点检测法和免疫比浊法检测393例肺癌患者、32例健康对照和77例肺部良性疾病患者血中纤维蛋白原(Fib)、D-二聚体(D-D)、纤维蛋白原降解产物(FDP)和β2-微球蛋白(β2-MG)的水平含量。结果肺癌患者的4种生物标志物水平均明显高于健康对照组和良性疾病组,差异有统计学意义(P<0.05)。4种指标检测肺癌的敏感度β2-MG最高,可达35.1%;其次为Fib可达27.2%;D-D(13.2%)和FDP(8.1%)较低,但特异度较高分别为98.8%和100%。4种生物标志物联合检测的敏感度可提高至55.5%,且特异度降低很少(88.1%)。结论四种生物标志物对于肺癌的辅助诊断有一定的临床意义,联合检测可以提高肺癌辅助诊断的敏感度。

Objective To explore the significance of combined or single application of four bio-markers for diagnosis of lung cancer.Methods Blood level of fibrinogen（Fib） was detected by coagulation point detection method and blood levels ofβ2-microglobulin（β2-MG）,fibrinogen degraded product（FDP） and D-dimer（D-D） were detected by transmission turbidimetric immunoassay in 32 healthy controls,393 patients with lung cancer and 77 patients with respiratory infection.Results The levels of these four bio-markers in patients with lung cancer were significantly higher than those of healthy controls and patients with respiratory infection（P0.05）.The sensitivity rates of β2-MG,Fib,D-D and FDP were 35.1%,27.2%,13.2% and 8.1% respectively.The specificity rates of D-D and FDP were 98.9% and 100% respectively.The sensitivity of these four tumor markers in diagnosis of lung cancer might be raised to 55.5%,if they were detected in combination,and their specificity was 88.1%.Conclusion These bio-markers are valuable auxiliary parameters in diagnosis of lung cancer.The sensitivity of combined detection of these four bio-markers in diagnosis of lung cancer can be raised.