重组人血管内皮抑素联合TACE对原发性肝癌血清VEGF表达的影响

The influence of recombinant human endostatin combined with TACE on the the serum VEGF expression of primary hepatocellular carcinoma

目的观察重组人血管内皮抑素联合肝动脉化疗栓塞术(TACE)对原发性肝癌血清血管内皮细胞生长因子(VEGF)表达的影响。方法 60例原发性肝癌患者分为两组,对照组(n=30)仅采用TACE治疗,观察组(n=30)在对照组治疗基础上加用重组人血管内皮抑素肝动脉栓塞治疗。观察和比较两组临床疗效,治疗前和治疗后第7、15、30 d血清VEGF表达水平。结果观察组治疗总有效率(60.0%)明显高于对照组(43.3%)(P<0.05);观察组术后VEGF表达水平逐渐下降(P<0.05),而对照组术后VEGF表达水平逐渐上升(P<0.05)。结论重组人血管内皮抑素可影响原发性肝癌血清VEGF表达水平,推测其对肿瘤血管生成具有一定的抑制作用。

Objective To observe the influence of recombinant human endostatin combined with TACE on the the serum VEGF expression of primary hepatocellular carcinoma.Methods 60 patients of primary hepatocellular carcinoma were divided into two groups,the control group（n=30） was only treated with TACE,and the observation group（n=30）was treated with recombinant human endostatin by hepatic artery embolization on the base of control group.The clinical efficacy of two groups,and the expression level of serum VEGF before treatment and the7,15,30 d after treatment were observed and compared.Results The total effective rate of observation group（60%） was significantly higher than that of control group（43.3%）（P0.05）.The expression level of VEGF in the observation group decreased gradually（P0.05）,while the expression level of VEGF in the control group increased gradually（P0.05）.Conclusion Recombinant human endostatin could affect the expression level of serum VEGF in primary hepatocellular carcinoma.It presumed that recombinant human endostatin had a certain inhibition to tumor angiogenesis.