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ABCC4基因与胃癌关系的研究进展 被引量：3

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摘要 胃癌为最常见的恶性肿瘤之一，据统计，在世界范围内，胃癌为第4位最常见的恶性肿瘤，在我国为第2位常见恶性肿瘤，其早期症状不明显、发展快、易转移及预后差，其发生发展的分子机制尚不十分清楚。
作者 张广钰 田小林
机构地区 桂林医学院附属医院胃肠外科
出处 《华夏医学》 CAS 2012年第6期920-923,共4页 Acta Medicinae Sinica
基金 2012年广西壮族自治区卫生厅科技项目(Z2012403)
关键词 基因 胃癌 相关性
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献22

  • 1Lin X,Ramamurthi K,Mishima M. P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin[J].Cancer Research,2001.1508-1516.
  • 2Lamba J K,Adachi M,Sun D. Nonsense mediated decay down regulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons[J].Human Molecular Genetics,2003,(02):99-109.doi:10.1093/hmg/ddg011.
  • 3Ravna A W,Sylte Ⅰ,Sager G. Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure[J].THEORETICAL BIOLOGY AND MEDICAL MODELLING,2009.20.
  • 4Adachi M,Sampoth J,Lan L B. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing[J].Journal of Biological Chemistry,2002,(41):38998-39004.
  • 5Toujani S,Dessen P,Ithzar N. High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma[J].PLoS One,2009,(09):e7089.
  • 6Yasui K,Mihara S,Zhao C. Alteration in copy numbers of genes as a mechanism for acquired drug resistance[J].Cancer Research,2004,(04):1403-1410.doi:10.1158/0008-5472.CAN-3263-2.
  • 7Sethi S,Benninger M S,Lu M. Noninvasive molecular detection of head and neck squamous cell carcinoma:an exploratory analysis[J].Diagnostic Molecular Pathology,2009,(02):81-87.doi:10.1097/PDM.0b013e3181804b82.
  • 8Kool M,de Haas M,Scheffer G L. Analysis of expression of cMOAT (MRP2),MRP3,MRP4,and MRPS,homologues of themultidrug resistance-associated protein gene (MRP1),in human cancer cell lines[J].Cancer Research,1997,(16):3537-3547.
  • 9Ravna A W,Sager G. Molecular modeling studies of ABC transporters involved in multidrug resistance[J].Mini Reviews in Medicinal Chemistry,2009,(02):186-193.
  • 10Russel F G,Koenderink J B,Masereeuw R. Multidrug resistance protein 4 (MRP4/ABCC4):a versatile efflux transporter for drugs and signalling molecules[J].Trends in Pharmacological Sciences,2008,(04):200-207.doi:10.1016/j.tips.2008.01.006.

二级参考文献9

  • 1Lin X,Ramamurthi K,Mishima M,et al.P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin.Cancer Res,2001,61:1508-1516.
  • 2Reid G,Wielinga P,Zelcer N,et al.Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.Mol Pharmacol,2003,63:1094-1103.
  • 3Schuetz JD,Connelly MC,Sun D,et al.MRP4:A previously unidentified factor in resistance to nucleoside-based antiviral drugs.Nat Med,1999,5:1048-1051.
  • 4Wielinga PR,Reid G,Challa EE,et al.Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.Mol Pharmacol,2002,62:1321-1331.
  • 5Norris MD,Smith J,Tanabe K,et al.Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblaioma and confers resistance to irinotecan in vitro.Mol Cancer Therapeutics,2005,4:547-553.
  • 6Gradilone A,Pulcinelli FM,Lotti LV,et al.Celecoxib upregulates multidrug resistance proteins in colon cancer:lack of synergy with standard chemotherapy.Curr Cancer Drug Targets,2008,8:414-420.
  • 7孙秀娣 牧人 周有尚 等.中国胃癌死亡率20年变化情况分析和及其发展趋势预测[J].中华肿瘤杂志,2002,24:101-105.
  • 8Kamangar F,Dores GM,Anderson WF.Patterns of cancer incidence,mortality,and prevalence across five continents:defining priorities to reduce cancer disparities in different geographic regions of the world.J Clin Oncol,2006,24,2137-2150.
  • 9Hagmann W,Jesnowski R,Faissner R,et al.ATP-binding cassette C transporters in human pancreatic carcinoma cell lines.Upregulation in 5-fluorouracil-resistant cells.Pancreatology,2009,9:136-144.

共引文献2

同被引文献34

  • 1洪成雨,郑建,李婷.p-ATM、p-p53及p-p21因子与进展期胃癌化疗疗效及预后的关系[J].实用癌症杂志,2014,29(1):13-16. 被引量：6
  • 2王海燕,姚桂芹,高佩增,闵令娥,韩丽.CA_(242),CEA,CA_(19-9)在胃癌及癌前病变组织中表达的相关研究[J].临床消化病杂志,2005,17(6):279-281. 被引量：19
  • 3Danielle Queiroz Calcagno,Mariana Ferreira Leal,Aline Damaceno Seabra,Andre Salim Khayat,Elizabeth Suchi Chen,Samia Demachki,Paulo Pimentel Assumpcao,Mario Henrique Girao Faria,Silvia Helena Barem Rabenhorst,Márcia Valéria Pitombeira Ferreira,Marília de Arruda Cardoso Smith,Rommel Rodríguez Burbano.Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma[J].World Journal of Gastroenterology,2006,12(38):6207-6211. 被引量：9
  • 4Norris MD, Smith 1, Tanabe K, et al. Expression of mult idrug transporter MRP4/ ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro [J]. Mol Cancer Ther, 2005,4(4) :547-553.
  • 5Hendig D, Langmann T, Zarbock R, et al. Characterization of the ATP - binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line [J]. Mol Cell Biochem, 2009, 328(1-2): 85-92.
  • 6Heimerl S, Bosserhoff AK, Langmann T, et al. Mapping ATPbinding cassette transporter gene expression profiles in melanocytes and melanoma cells[J]. Melanoma Res, 2007,17 (5): 265-273.
  • 7Holla VR, Backlund MG, Yang P, et al. Regulation of prostagl andin transporters in colorer-tal neoplasia [J]. Cancer Prev Res: Phila Pa, 2008,1 (2) :93-99.
  • 8Gillet 1P, Efferth T, Steinbach D, et al. Microarray-based detection of multi drug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes [J]. Cancer Res, 2004,64(24) :8987-8993.
  • 9Beretta GL, Benedetti V, Cossa G, et al. Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin [J]. Biochem Pharmacol, 2010,79 (8): 1108-1117.
  • 10Dong Y, Zhang H, Gao AC, et al. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers [J]. Mol Cancer Ther, 2005,4 (7) : 1047-1055.

引证文献3

二级引证文献4

华夏医学
2012年 第6期

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