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非小细胞肺癌EML4-ALK融合基因的检测及临床应用进展 被引量：1

Advances in Detection and Clinical Applications of EML4-ALK Fusion Gene in Non-small Cell Lung Cancer
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摘要 分子靶向治疗是目前最具前景的研究领域,而融合基因分子靶点检测是分子靶向治疗的前提。EML4-ALK融合基因是新近发现主要表达于非小细胞肺腺癌中,可能与非小细胞肺癌表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)耐药相关,文章就其发现过程以及临床应用进行综述。
作者 曹卓 王良兴
机构地区 丽水市人民医院 温州医学院
出处 《肿瘤学杂志》 CAS 2012年第11期830-834,共5页 Journal of Chinese Oncology
关键词 癌 非小细胞肺 EML4-ALK 表皮生长因子受体 酪氨酸激酶抑制剂
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献23

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二级参考文献40

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共引文献26

同被引文献3

  • 1Soda M,Takada S,Takeuchi K,et al.A mouse model for EML4- ALK-positive lung cancer [J].Proc Natl Acad Sci US,2008,105 (50):19893-19897.
  • 2Inamura K,Takeuchi K,Togashi Y,et al.EML4-ALK fusion is linked to histological characteristics in a subset of lung can- cers[J].Mod Patho,2009,22(4):508-515.
  • 3Shaw AT,Yeap BY,Mino-Kenudson M,et al.Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK[J].J Clin Onco,2009,27(26):4247-4253.

引证文献1

二级引证文献1

肿瘤学杂志
2012年 第11期

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