血清同型半胱氨酸水平与冠心病相关性的临床分析

The Clinical Analysis of Correlation of Serum Homocysteine Level with Coronary Heart Disease

目的:分析血清同型半胱氨酸(Hcy)水平与冠心病(CHD)的临床相关性,提高对CHD的防治水平。方法:选择2011年2月～2012年6月在我院就诊且确诊为CHD的患者82例,按照患者CHD的类型、冠状动脉病变支数和狭窄程度进行分组后,检测和比较患者血清Hcy水平,并分析其与冠心病严重程度、冠状动脉病变支数和狭窄程度的相关性。结果:血清Hcy水平与CHD的严重程度、冠状动脉病变支数和冠状动脉狭窄程度均呈显著正相关(r=0.716,r=0.738,r=0.802,P<0.05)。结论:血清Hcy水平与CHD的发生发展密切相关,通过动态检测患者血清Hcy水平可有助于预测CHD病变的发展并评估患者的预后。

Objective： To analyze the clinical correlation of serum homocysteine（Hcy） level with coronary heart diseas and improve the prevention and treatment of coronary heart disease（CHD）.Methods： 82 cases of CHD hospitalized in our hosptoal from Febuary 2011 to June 2012 were selected and randomly divided into different groups according to the type of CHD,number of diseased coronary arteries and degree of coronary artery stenosis.The serum Hcy level was detected and compared among different groups,and the correlations of serum Hcy level with severity of CHD,number of diseased coronary arteries and degree of coronary artery stenosis were analyzed.Results： The serum Hcy level were positively correlated with the severity of CHD,number of diseased coronary arteries and degree of coronary artery stenosis（r=0.716,r=0.738,r=0.802,P0.05）.Conclusion： The serum homocysteine level was closely related to the CHD,dynamic detection of which may contribute to predict and evaluate the development and prognosis of CHD.