GC/MS/Xcalibur技术自动分析疑似固体中管制药物

Automatic Detection of Control Drugs with GC/MS-Xcalibur

目的建立疑似含毒检材中国家管制药品的自动筛选方法。方法以我国2007年公布的精神药品和麻醉药品的品种目录为检测目标物,建立质谱用户库;以此为基础,设置气质联用仪自动分析方法对疑拟检材进行常见管制药品的快速筛选。结果建立了库名含多种实用信息、包括230种管制药品的质谱用户库;建立管制药品的质谱自动分析方法,实现"一针分析出结果"。结论方法简单、快速、准确可靠,省时省力,能有效提高可疑检材中管制药品筛选分析的速度。

Objective To develop an automatic screening method for the identification of national control drugs.Method A mass spectrum library of national control drugs on the list of Narcotic Drugs and Psychotropic Substances under National Control（2007） was established.Then,with an automatic GC/MS method,common control drugs in suspected samples were screened rapidly.Results A library containing the mass spectra of 230 national control drugs and related useful information has been built.An automated screening method for control drugs with GC/MS has been set up.Conclusion The method is simple,quick and reliable.It can be used for the rapid screening of national control drugs in suspected samples.