利福平胶囊粉外敷治疗卡介苗接种后脓肿致药物性肝炎

Drug-induced hepatitis caused by local application of rifampicin capsule powder for abscess after BCG vaccination

1例7月龄女婴,因出生后注射卡介苗,4个月后左上臂出现脓肿。局部外敷利福平胶囊粉,约37.5 mg,1次/d,用药1个月后局部无好转。实验室检查:丙氨酸转氨酶126 U/L,天冬氨酸转氨酶106 U/L。停用利福平胶囊粉局部外敷,给予还原性谷胱甘肽护肝,五酯胶囊降酶,并对脓肿行局部切开引流,清除干酪样坏死组织。19 d后患儿左上臂切口愈合,肝功能好转出院。出院后1个半月复查,肝功能完全恢复正常。

A 7-month-old female child developed an abscess on her left upper arm due to BCG vaccination 4 months after birth. She treated with local application of rifampicin capsule powder about 37.5 mg/d for one month, but with no improvement. Laboratory examination showed the following results： alanine aminotransferase 126 U/L, aspartate aminotransferase 106 U/L. The local application of rifampicin capsule powder was stopped, reduced glutathione was given to protect her liver, Wuzhi capsules （五酯胶囊） was given to reduce enzyme level, as well as incision and drainage of the abscess were performed and caseous necrotic tissue was cleared away. Nineteen days later, the child＇s lesion on her left upper arm healed, her liver function improved and she was discharged. Her liver function returned comoletelv to normal one and half month after discharge_